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In a forced swim test in rats, MI administration reduced depressive behavior, which was abolished by the addition of the specific 5-HT 2A /5-HT 2C antagonist ritanserin, but not the 5-HT 1A /5-HT 1B /β adrenergic antagonist pindolol, which suggests that the MI anti-depressant mechanism specifically involves 5-HT 2 subtype receptors [238]

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Most patients experience no adverse reactions, but in rare cases, individuals may report symptoms such as mild bloating, cramping, allergic reactions (rash or itching), or a metallic taste in the mouth