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doi: 10.3389/fmed.2026.1730795 Received 23 October 2025 Revised 06 March 2026 Accepted 23 March 2026 Published 02 April 2026 Corrected 05 June 2026 Volume 13 - 2026 Edited by Andrea Tinelli, Veris Delli Ponti Hospital, Italy Reviewed by Feng Zhang, Nanjing University of Chinese Medicine, China Minghong Sun, Southwest University, China Updates Copyright © 2026 Lv, Li, Ding and Kuang

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Furthermore, DHA can be hydrolyzed into 2,3-l-diketogulonate, being further oxidized to unknown intermediate (Figure 2) and catalyzed by ascorbate oxidase (AO)