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Chen et al., 2003) and overexpression of Nrf1 and Nrf2 has been shown to induce the human GCLC promoter activity (Myhrstad et al., 2001

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A 2022 review and meta-analysis found that doses as low as 50mg per day could have a reductive effect on cholesterol,37 and we know from other research that high cholesterol can lead to liver fibrosis.38 The same 2022 review found that at least 500mg of artichoke leaf per day provided the greatest impact on liver markers like ALT and AST.37 However, certain users should be aware of serious side effects when ingesting artichoke