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Supplementary material The Supplementary Material for this article can be found online at: Glossary apoA1 Apolipoprotein A1 LDGs Low-Density Granulocytes AS atherosclerosis LOX-1 Lectin-like oxidized low-density lipoprotein receptor-1 ASCVD atherosclerotic cardiovascular disease LPS Lipopolysaccharide BAFF B-cell-activating factor MAPKs Mitogen-activated protein kinases CACs circumferential artery cells MDA malondialdehyde CAD coronary artery disease MMF Mycophenolate mofetil cGAS-STING cyclic GMP-AMP synthase - stimulator of interferon genes pathway MMP Matrix Metalloproteinase CPA cyclophosphamide MPO Myeloperoxidase CVDs cardiovascular diseases MyD88 myeloid differentiation factor 88 DMB 3,3-dimethyl-1-butanol NETs Neutrophil Extracellular Traps DNase I Deoxyribonuclease I NF-κB Nuclear Factor Kappa B ECM extracellular matrix NOX NADPH Oxidase EPCs endothelial progenitor cells NOS Nitric Oxide Synthase FMO3 flavin monooxygenase 3 Ox mtDNA Oxidized Mitochondrial DNA FMT Fecal Microbiota Transplantation oxLDL Oxidized Low-Density Lipoprotein HCQ hydroxychloroquine PAD Peptidylarginine Deiminase HDL High-Density Lipoprotein PC Phosphatidylcholine HFD high-fat diet pDCs Plasmacytoid Dendritic Cells HGF hepatocyte growth factor PD-L1 programmed death ligand 1 HMGB1 High Mobility Group Box 1 PKM2 pyruvate kinase M2 IAA indole-3-acrylic acid PON1 Paraoxonase 1 I3C Indole-3-carbinol ROS Reactive Oxygen Species ICAM-1 Intercellular Adhesion Molecule-1 SCFAs Short-Chain Fatty Acids ICs immune complexes SLE systemic lupus erythematosus IDO1 indoleamine 2,3-dioxygenase 1 SR-A1 scavenger receptor A1 IFN-I Type I interferons Tang cells CD3+CD31+CXCR4+ angiogenic T-cells TYK2/JAK1 IFNAR-mediated JAK kinase Tfh Follicular helper T-cells iNKT Invariant Natural Killer T-cells Th1 CXCR3+ T helper 1 cells IPA indole-3-propionic acid TJPs Tight Junction Proteins IRF Interferon regulatory factor TLR Toll-like receptors ISGs interferon-stimulated genes TMA Trimethylamine ISRE interferon-stimulated response element TMAO Trimethylamine-N-Oxide JAKi Janus kinase inhibitors VCAM-1 Vascular Cell Adhesion Molecule-1 LBP Lipopolysaccharide Binding Protein VEGF vascular endothelial growth factor LDL low-density lipoprotein VSMC vascular smooth muscle cell

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Timestamps 0:00 The one-leg study, and the muscle-centric claim 02:06 What obesity is, and the garage analogy 05:06 How glucose gets into a muscle cell 11:21 Insulin sensitivity improves without building muscle 17:11 The best case for muscle-centric medicine 21:13 What predicts falls and death: strength, not lean mass 25:18 Separating muscle size from muscle function 31:33 Liver fat: amount, type, and flux 37:54 Should you build muscle first