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(2017, Cell) used intraperitoneal injections of 10 mg/kg in fast-aging XFE progeroid mice and naturally aged mice

reduce pigmentation

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Benfotiamine is a fat-soluble derivative of thiamine that has much greater bioavailability than other forms of thiamine, and is capable of reaching concentrations in the bloodstream several times that of orally administered thiamine (Greb 1998