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Variations in the MTHFR gene can affect how the body metabolises B vitamins, including B12

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Similarly, in GPx1 −/− mice, deficiency of GPx1 increased ROS (as measured by DCF fluorescence of brain homogenates), lipid peroxidation, and protein carbonylation in brains exposed to the Aβ peptide, whereas forced overexpression of GPx1 in the GPx1 −/− mice attenuated these detrimental effects [124]