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Fibroblast growth factor 21 (FGF21) inhibits macrophage-mediated inflammation by activating Nrf2 and suppressing the NF-kappaB signaling pathway

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Following administration: Topical penetration through stratum corneum confirmed in skin permeability studies Systemic distribution following parenteral administration with preferential accumulation at injury sites Enhanced bioavailability compared to free copper due to peptide transport mechanisms Cellular uptake facilitated by specific copper transport pathways and receptors Studies using copper-64 radiolabeling showed preferential distribution to metabolically active tissues and sites of inflammation or injury, suggesting injury-targeted delivery mechanisms