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In a clinical trial on human subjects, a topical preparation of the peptide reduced the appearance of forehead wrinkles and crow’s feet.31 Argirelox Argirelox is a peptide blend that contains acetyl hexapeptide-8, whose mechanism of action is similar to that of Botox.22 Acetyl hexapeptide-8 has demonstrated the ability to reduce the appearance of wrinkles,23 but more research is needed, as some other research has found the peptide’s effects to be unremarkable.24 The other peptide in the complex is pentapeptide-18, also known as Leuphasyl