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Addressing these gaps requires multi-dimensional studies integrating single-cell omics, spatial transcriptomics, and clinical cohort analyses to resolve pathway crosstalk, define cell type-specific roles, and bridge preclinical and clinical translation, ultimately advancing ferroptosis-targeted strategies from bench to bedside in AKI treatment

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Within the barrel-stave model, the aNDB molecules are initially oriented parallel to the membrane but eventually inserted perpendicularly in the lipid bilayer (Hegde et al., 2022) (Figure 4)