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Retatrutide’s Phase 2 monotherapy weight loss (~24.2% at 48 weeks) is numerically larger than cagrilintide’s (~10.8% at 26 weeks), but those come from different trials, durations, and doses, and cagrilintide’s strongest data are as the CagriSema combination

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Earlier oral trial METAOD005 randomized 300 adults with obesity to oral AOD-9604 (1, 5, 10, 20, or 30 mg/day) or placebo for 12 weeks