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On the other hand, those with methylation issues (MTHFR gene mutations carriers, for instance) do best on methylated B12, that is, methylcobalamin
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Cuprizone-fed mice with demyelination treated by Tβ4 exhibited a significant increase of remyelination, accompanied with a robust increase of newly generated OLs, and elevation of MBP density in the demyelinating corpus callosum (Zhang et al., 2016b)