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Baker’s notes & crumb story
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Under energy stress conditions (such as glucose deprivation or hypoxia), the binding of AMP or ADP to the γ regulatory subunit induces a conformational change in the AMPK complex, increasing its sensitivity to upstream kinases
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MI exerts indirect anti-inflammatory actions by normalizing insulin and lipid metabolism, reducing activation of the NLRP3 inflammasome, and decreasing systemic cytokine output (Ref)