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Multivariable Cox regressions adjusting for demographics confirmed this association: participants with high polygenic risk had 82% lower risk of ICH compared to those with low polygenic risk (HR:0.18, 95%CI:0.04-0.82, p = 0.026), persisting in sensitivity analysis including measured LDL-c levels and statin use

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303,443 In the meantime, by utilizing the results of GWAS studies, clinicians can identify individuals at risk for adverse drug reactions better, thereby improving safety and treatment compliance